Do NOT use Diflucan if:

• you are allergic to any ingredient in Diflucan
• you are taking astemizole, an aldosterone blocker (eg, eplerenone), cisapride, an ergot alkaloid (eg, ergotamine), erythromycin, pimozide, a serotonin (5-HT₁) receptor agonist (eg, eletriptan), or terfenadine.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Diflucan. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have a weakened immune system, kidney or liver disease, or an irregular heartbeat
• if you are allergic to other azole antifungals (eg, itraconazole).

Some medicines may interact with Diflucan. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Aldosterone blockers (eg, eplerenone), amiodarone, astemizole, cisapride, pimozide, serotonin receptor agonists (eg, eletriptan), macrolide antibiotics (eg, erythromycin), quinolines (eg, ciprofloxacin), or terfenadine because the risk of severe irregular heartbeat (eg, QT prolongation) may be increased
• Rifabutin because the risk of certain eye problems (eg, uveitis) may be increased
• Macrolide immunosuppressants (eg, tacrolimus) because the risk of kidney problems may be increased
• Rifampin or proton pump inhibitors (eg, omeprazole) because they may decrease Diflucan's effectiveness
• Anticoagulants (eg, warfarin), benzodiazepines (eg, alprazolam), buspirone, carbamazepine, cyclophosphamide, cyclosporine, ergot alkaloids (eg, ergotamine ), haloperidol, HMG-CoA reductase inhibitors or "statins" (eg, simvastatin), hydantoins (eg, phenytoin), methadone, muscarinic antagonists (eg, solifenacin, tolterodine), narcotics (eg, codeine), ramelteon, sulfonylureas (eg, glipizide), theophylline, or tricyclic antidepressants (eg, amitriptyline) because the risk of their side effects may be increased by Diflucan.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Diflucan may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

• Diflucan may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Diflucan with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
• Diflucan has been known to cause rare cases of serious liver damage, including death, mainly in patients with serious medical conditions. Liver damage caused by Diflucan has not been attributed to total daily dose, length of therapy, or sex or age of the patient. This type of liver damage may or may not be reversible when Diflucan is stopped. If you notice any of the following, contact your doctor immediately: swollen or tender abdomen, yellowing of the skin or eyes.
• Be sure to use Diflucan for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The fungus could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.
• Diflucan may cause a rash. If the rash worsens, contact your doctor.
• Long-term or repeated use of Diflucan may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.
• Hormonal birth control (eg, birth control pills) may not work as well while you are using Diflucan. To prevent pregnancy, use an extra form of birth control (eg, condoms).
• Lab tests, such as blood urea nitrogen and liver and kidney function, may be performed while you use Diflucan. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
• Use Diflucan with caution in the elderly; they may be more sensitive to its effects.
• Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Diflucan while you are pregnant. Diflucan is found in breast milk. If you are or will be breast-feeding while you use Diflucan, check with your doctor. Discuss any possible risks to your baby.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Changes in taste; dizziness; headache; nausea; stomach pain.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); diarrhea; scaly, red skin over a large portion of the body; swollen or tender abdomen; vomiting; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects.